119 articles - From Friday Jul 01 2022 to Friday Jul 08 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review. Methods The Best Practice Advice statements presented here were developed from expert review of existing literature combined with discussion and expert opinion to provide practical advice. Formal rating of the quality of evidence or strength of BPAs was not the intent of this clinical practice update. |
| Gastroenterology |
CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease. This multidisciplinary collaboration involving patients and clinical experts has produced the first COS that can be applied to RCTs of CD and UC. |
| Gut |
British Society of Gastroenterology guidelines on the management of functional dyspepsia. These provide both the strength of the recommendations and the overall quality of evidence. Finally, in this guideline, we consider novel treatments that are in development, as well as highlighting areas of unmet need and priorities for future research. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Living in the non-alcoholic fatty liver disease silent epidemic: a qualitative systematic review of patients' perspectives. This review synthesises first-hand accounts of individuals with NAFLD. With the growing burden of NAFLD, future public interventions must consider individual views for success to be found. The identified themes serve as a forefront for consideration for public policies. Ultimately, NAFLD is a multisystem disease, which must be managed by a multidisciplinary team. |
| Endoscopy |
Long-Term Outcomes of Per-Oral Endoscopic Myotomy (POEM) for Achalasia: a Systematic Review and Meta-analysis. Long-term clinical efficacy of POEM persists in nearly 87% of patients with achalasia. Post-POEM symptomatic reflux seems to remain stable over time. Risk for Barrett's esophagus and peptic strictures appears minimal. |
| Gastroenterology |
Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants. Liver stiffness assessed by MRE is associated with liver-related events and the combination of MRE and FIB-4 has excellent negative predictive value for hepatic decompensation. These data have important implications for clinical practice. |
| Inflamm Bowel Dis |
Alterations in the Course of Inflammatory Bowel Disease Following Liver Transplantation: A Systematic Review and Meta-analysis. We conclude that IBD activity remains unchanged (or improved/unchanged) in most IBD patients following LT. Furthermore, IBD type, age, and follow-up length can influence the IBD course after LT. |
| J Crohns Colitis |
Psychiatric disorders in adult and paediatric patients with inflammatory bowel diseases - a systematic review and meta-analysis. The prevalence of psychiatric comorbidities was high (11- 82%) in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Classic drugs in the time of new drugs: Real-world, long-term outcomes of thiopurine monotherapy in 1016 patients with inflammatory bowel disease. In real-world practice, thiopurine monotherapy remains an effective, safe and durable treatment option for patients with CD or UC, including in the era of biologics. |
Impact of Rome IV Irritable Bowel Syndrome on Work and Activities of Daily Living. Patients with IBS experience a substantial impact on their work and activities of daily living because of their IBS. Future studies should assess the impact of medical interventions on the ability to work and participate in social activities. |
Impact of thiopurines and tumour necrosis factor antagonists on primary sclerosing cholangitis outcomes in patients with inflammatory bowel disease. Patients with PSC and IBD who are exposed to thiopurines or anti-TNF agents are not at excess risk of biliary tract cancer or liver transplantation. |
Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study. UC and CD are associated with slightly increased all-cause dementia risk, particularly frontotemporal dementia in CD patients. Frequent healthcare system contacts by patients with IBD and detection bias may play a role in the association. |
Treatment patterns of anti-tumour necrosis factor-alpha and prognosis of paediatric and adult-onset inflammatory bowel disease in Korea: a nationwide population-based study. These data demonstrate that the prevalence of IBD has increased over time, especially among paediatric patients. Given the magnitude of paediatric IBD disease burden, a multi-faceted approach is needed for early detection and vigilant monitoring to aim for better prognosis. |
| Gastroenterology |
Acetyl-coA Synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer. ACSS2-mediated metabolic reprogramming activates ZIP4 pathway, and promotes macropinocytosis via SDC1/DNM2 and drives muscle wasting through GSK3ß/TRAIL axis, which potentially provides additional nutrients for macropinocytosis in pancreatic cancer. |
Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites. We generated cross-cohort metagenomic signatures of CRC, some of which linked to in-house CRC-associated serum metabolites. The microbial and metabolic shifts may have wide population relevance. |
Malondialdehyde-acetaldehyde extracellular matrix protein adducts attenuate unfolded protein response during alcohol and smoking-induced pancreatitis. The combined alcohol and smoking generate stable MAA-ECM adducts that increase ER stress and acinar cell death due to attenuated UPR and suppress the expression of cell cycle regulators. Targeting aldehyde-adducts might provide a novel therapeutic strategy for the management of RAP and CP. |
Population-level metagenomics uncovers distinct effects of multiple medications on the human gut microbiome. Our large-scale metagenomics unravels extensive and disruptive impacts of individual and multiple drug exposures on the human gut microbiome, providing a drug-microbe catalog as a basis for a deeper understanding of the role of the microbiome in drug efficacy and toxicity. |
Radiomics-Based Machine Learning Models Can Detect Pancreatic Cancer on Prediagnostic CTs at a Substantial Lead Time Prior to Clinical Diagnosis. Radiomics-based ML models can detect PDAC from normal pancreas when it is beyond human interrogation capability at a substantial lead time prior to clinical diagnosis. Prospective validation and integration of such models with complementary fluid-based biomarkers has the potential for PDAC detection at a stage when surgical cure is a possibility. |
| Gastrointest Endosc |
Improving 30-day mortality following percutaneous endoscopic gastrostomy tube placement in England from 2007 to 2019: a retrospective national cohort analysis of 87,862 patients. 30 day mortality following PEG insertion has fallen 60% over 13 years. Dementia or stroke as a PEG indication fell and the time interval from stroke to PEG insertion increased. These findings may be attributable to improved patient selection and timing for PEG insertion. |
Tip-in Endoscopic Mucosal Resection as an Alternative to Endoscopic Submucosal Dissection for 20-30-mm Non-Pedunculated Colorectal Neoplasms. Tip-in EMR is comparable to ESD with respect to the local recurrence rate but has a shorter procedure time, despite the lower en bloc and R0 resection rate for 20-30-mm non-pedunculated colorectal neoplasms without fold convergence or non-lifting sign. Thus, Tip-in EMR could be a feasible alternative to ESD in these lesions. |
| Gut |
Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients. Objective Autoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells, eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at elucidating the natural history, histological phenotype(s), and associated cancer risk of patients with AIG consistently tested comorbidity. |
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study. Genotyping was performed using the InfiniumGlobal Screening Array (V.24v2, Illumina) and the OmniExpress Array (V.24v1-0a, Illumina). Results Associations with variants rs738409 in as a novel protective factor for HCC in patients with alcohol-related cirrhosis. |
| Hepatology |
ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver. Hepatic endothelial ALK1 signaling protects from development of vascular malformations preserving organ-specific endothelial differentiation and angiocrine signaling. The long-term surviving Alk1 HEC-KO HHT model offers novel opportunities to develop targeted therapies for this severe disease. |
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease. Our data uncover the importance of a lipid membrane composition rich in DHA and its lipid autacoid derivatives to have optimal hepatic mitochondrial and metabolic efficiency. |
RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling. These findings provide new mechanistic insight into the role of DDX5 in mTORC1 regulation and NASH progression, as well as suggest a number of new targets and a promising lead compound for therapeutic interventions against NASH. |
| Inflamm Bowel Dis |
Indirect Costs of Inflammatory Bowel Diseases: A Comparison of Patient-Reported Outcomes Across 12 European Countries. The study showed a high relevance of the indirect cost of IBD in the context of economic evaluation, as well as a between-country variability of work-related impairment or informal care. |
Primary Care Professionals' Attitudes Towards Vaccination Recommendation for Patients With Inflammatory Bowel Disease. There is room for improvement of vaccination recommendations by PCPs. Promoting continuing education and use of clinical tools may help support PCP immunization practices for patients with IBD. |
The Risk of Serious Infections Before and After Anti-TNF Therapy in Inflammatory Bowel Disease: A Retrospective Cohort Study. In routine clinical practice in Sweden, the incidence rate of serious infection among IBD patients did not increase with anti-TNF therapy. Instead, serious infections seemed to decrease more than 1 year after initiation of anti-TNF treatment. |
Trends in Medical Management of Moderately to Severely Active Ulcerative Colitis: A Nationwide Retrospective Analysis. As biologic drugs have become increasingly available for UC management, they have increasingly been used at earlier stages of disease management. Large-scale analyses of prescribing behaviors provide evidence supporting early use of biologics compared with step-up therapy and use of thiopurine and biologic combination therapy. |
| J Crohns Colitis |
Biological therapy for budesonide-refractory, -dependent or -intolerant microscopic colitis: a multicentre cohort study from the GETAID. This is the first multicentre cohort study showing that half of patients treated with anti-TNF therapy for MC achieved clinical remission in case of budesonide failure. |
Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicenter Case Series. To date, this is the largest case series of patients with IBD and HCCS. The most frequent diagnosis of HCCS associated with IBD was Lynch syndrome. These data demonstrate the high malignancy rate and surgical intervention rate in this IBD cohort, despite the endoscopic surveillance. The optimal medical approach still needs to be addressed. |
Hypoxia-Inducible Factor 1-Alpha Stabilizers in the Treatment of Inflammatory Bowel Diseases: Oxygen as a Novel IBD Therapy? In line with these criteria, hypoxia-inducible factor (HIF)-1a stabilizers, acting via inhibition of prolyl hydroxylase enzymes, are emerging as an innovative therapeutic strategy. We herein review the mechanism of action and available clinical data for HIF-1a stabilizers and its potential place in the future IBD treatment algorithm. |
Increased Risk of Non-Conventional and Invisible Dysplasias in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease. Nearly a third of PSC-IBD patients developed dysplasia, which is often associated with non-conventional dysplastic features, invisible endoscopic/gross appearance, right/proximal-sided colon, multifocality, and advanced neoplasia on follow-up. These findings underscore the importance of recognizing these non-conventional subtypes by practicing pathologists and the need for careful and frequent endoscopic surveillance with random biopsies in PSC-IBD patients. |
Timing of live attenuated vaccination in infants exposed to infliximab or adalimumab in utero: A prospective cohort study in 107 children. Almost one quarter of infants born to mothers receiving anti-TNF during pregnancy have detectable anti-TNF at 6 months. In order to limit the time to live-attenuattated vaccination in infants of mothers receiving anti-TNF during pregnancy, the results of a cord drug level at birth and a 2 nd sample =1 month thereafter can be used to estimate the time for full anti-TNF clearance in these children. |
| J Hepatol |
Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH. Fibrosis regression following hepatic fat reduction occurs initially in the perisinusoidal regions, around areas of steatosis reduction. Digital pathology provides new insights in treatment-induced fibrosis regression in NASH, which are not captured by current staging systems. |
Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis. Cholangitis is characterised by intrahepatic expansion and inflammatory maturation of type 2 conventional dendritic cells in response to biliary injury. Therefore, type 2 conventional dendritic cells and their inflammatory mediators might be potential therapeutic targets for the treatment of PSC. |
Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis. LSM by VCTE is a major, independent, validated predictor of PBC outcome. Its value as a surrogate endpoint for clinical benefit in PBC should be considered. |
| J Neurogastroenterol Motil |
Saccharomyces boulardii and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial. Methods This open-label randomized controlled trial was conducted at 10 university hospitals in Korea. Children who were diagnosed with functional constipation were allocated to 3 groups (lactulose monotherapy, combination therapy, and monotherapy was not superior to lactulose monotherapy or combination therapy and showed a higher drug change rate, supporting the current recommendation of probiotics in the treatment of childhood functional constipation. |
A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease. Background/aims Chagasic megacolon is caused by -induced damage of smooth muscles was accompanied by motility disorders such as decreased intestinal peristalsis and cholinergic system response impairment. This study allows integration of the natural history of Chagasic megacolon motility disorders and opens new perspectives for the design of effective therapeutic. |
Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population. In the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD. |
Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer. Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes. |
Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia. The 30-minute slow nutrient drinking test is a minimally invasive method of effectively evaluating symptoms of postprandial distress syndrome among patients with FD, in Japan. |
General Well-being and Coping Strategies in Adult Eosinophilic Esophagitis Patients. EoE has a significant negative impact on mental HRQOL, with less effective coping strategies--specifically in males, being a relevant determinant. Thus, a pro-active approach towards coping mechanisms is needed in order to enhance HRQOL and manage patients' burden of EoE. |
Normal Values of High-resolution Anorectal Manometry of Healthy Indians. The present study provides normal data for the Indian population that can be used for comparison and further work. Age, gender, and BMI affect anorectal parameters in HRAM and should be considered while reporting. |
Risk Factors for Self-reported Irritable Bowel Syndrome With Prior Psychiatric Disorder: The Lifelines Cohort Study. Despite its limitations this study suggests that prior psychiatric disorder is an important risk factor in a quarter of IBS onsets. Negative health perception and multiple bodily symptoms are associated with al IBS onsets in line with the cognitive-behavior model of IBS. Prior psychiatric disorder may predict an optimal response to psychiatric treatment. Further studies could usefully study mechanisms linking IBS to prior psychiatric disorder. |
Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance. The results suggested that elobixibat was well-tolerated and efficacious in elderly patients with chronic constipation and can be administered before any meals. |
The Predictive Value of Intraoperative Esophageal Functional Luminal Imaging Probe Panometry in Patients With Achalasia Undergoing Peroral Endoscopic Myotomy: A Single-center Experience. While FLIP panometry was not significantly associated with the clinical course of achalasia, FLIP panometry was associated with POC following POEM and may complement manometry in the functional evaluation of esophageal motility disorders. |
The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter. A higher UES-DI measures defective barrier function which could may be the main pathophysiology that generates supra-esophageal symptoms. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: Exclude or expose? The paradox of conceptually opposite treatments for irritable bowel syndrome. Even though exclusion diets and exposure-based CBT are conceptually opposite, they each have proven efficacy. Clinicians should familiarise themselves with both treatments. Further research is needed on predictors, mechanisms and moderators of treatment outcomes. |
| Gastroenterology |
| Inflamm Bowel Dis |
| J Hepatol |
Augmenter of liver regeneration: mitochondrial function and steatohepatitis. Whereas high-fat diet-fed ALR-deficient mice develop nonalcoholic steatohepatitis (NASH) and fibrosis, hepatic and serum levels of ALR are lower than normal in human NASH and NASH-cirrhosis. Thus ALR deficiency may be a critical predisposing cause for the pathogenesis and progression of NASH. |
COVID-19 positive donor for solid organ transplantation. As the evolving outbreak of SARS-CoV-2 continues, alongside the presence of vaccines and new treatment options, clinicians should consider transplanting organs from deceased donors with active SARS-CoV-2 infection to recipients with limited opportunities for transplantation and natural or vaccine induced specific immunity. This article seeks to describe an expert opinion for the use of organs from deceased donors with resolved or active SARS-CoV-2 infection in the absence of more definitive data and standardized acceptance patterns. |
| J Neurogastroenterol Motil |
How to Implement the 3-Phase FODMAP Diet Into Gastroenterological Practice. While the diet has shown improved irritable bowel syndrome outcomes across studies, it is important to acknowledge the essential role of dietitians in implementing, tailoring, and managing the diet to achieve the best outcome for each individual. |
Letters to the editors and authors’ replies
| Gut |
| Hepatology |
| Inflamm Bowel Dis |
| J Hepatol |
| J Neurogastroenterol Motil |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Inflamm Bowel Dis |
| J Crohns Colitis |
| J Hepatol |